Sant'Antonio Abate is a comune (municipality) in the Province of Naples in the Italian region Campania, located about 30 km southeast of Naples. As of 31 December 2004, it had a population of 18,806 and an area of 7.9 km².
Sant'Antonio Abate borders the following municipalities: Angri, Gragnano, Lettere, Pompei, Santa Maria la Carità, Scafati.