The Basilica of the National Shrine of the Assumption of the Virgin Mary, also called the Baltimore Basilica, was the first Roman Catholic cathedral built in the United States, and was the first major religious building constructed in the nation after the adoption of the U.S. Constitution. As a co-cathedral, it is one of the seats of the Roman Catholic Archdiocese of Baltimore in Baltimore, Maryland.

The Cross Street Market, a recently-renovated historic marketplace built in the 19th century, continues to serve residents and is the primary social and commercial hub for the neighborhood. The primary business district is bounded by Montgomery, Ostend, Light, and Hanover Streets, and is home to a large number of restaurants of a wide range of taste, quality, and price, and many small shops as well as a few larger, more practical stores. The neighborhood is a popular destination for tavern goers and music lovers, with street festivals several times a year. These are organized through a very active neighborhood organization and business organization, as is the annual Shakespeare on the Hill series of summer performances in the park atop the actual Federal Hill. The neighborhood is also home to the American Visionary Art Museum and Maryland Science Center.

Druid Hill Park is a 745-acre park in Baltimore, Maryland. The land was originally part of the Druid Hill estate of Nicholas Rogers, and was purchased by the city of Baltimore with the revenue derived from a one-cent park tax on the nickel horsecar fares. Druid Hill Park was inaugurated by Baltimore Mayor Thomas Swann on October 19, 1860.

The park was a popular destination for city dwellers for a number of years. The park features a number of waterways, most notably Druid Hill Lake. With the advent of automobiles, the park's many winding roadways became popular with car dealers who took potential buyers there to teach them to drive.

Today, the park is home to a number of attractions, including The Maryland Zoo, the recently renovated conservatory, an 18-hole disc golf course, and the Baltimore Model Safety City, where school children learn how to be safe pedestrians by walking in a miniaturized model of downtown Baltimore.

The American Visionary Art Museum (AVAM) is an art museum located in the Federal Hill neighborhood of Baltimore, Maryland. The city agreed to give the museum a piece of land on the south shore of the Inner Harbor under the condition that its organizers would clean up residual pollution from a copper paint factory and a whiskey warehouse that formerly occupied the site. It has been designated by Congress as America's national museum for self-taught art.

The Baltimore Museum of Art in Baltimore, Maryland, was founded in 1914. It is located between the Charles Village and Remington neighborhoods, immediately adjacent to the Homewood campus of Johns Hopkins University, though the museum is an independent institution not affiliated with Hopkins.

The Walters Art Museum, located in Baltimore, Maryland's Mount Vernon neighborhood, is a small privately-formed art collection open to the public. The museum's collection was amassed substantially by two men, William Thompson Walters ( –1894), who began serious collecting when he moved to Paris at the outbreak of the American Civil War, and Henry Walters (1848–1931), who refined the collection and rehoused it in a palazzo. The Walters Gallery opened to the public on Wednesdays in April and May, in 1875. The collection touches masterworks of ancient Egypt, Greek sculpture and Roman sarcophagi, medieval ivories, illuminated manuscripts, Renaissance bronzes; Old Master and 19th-century paintings; Chinese ceramics and bronzes; and Art Deco jewelry.

In the fall of 2001, the Walters reopened its largest building after a dramatic three-year renovation. The Walters Art Museum is where the Archimedes Palimpsest may be seen.

Starting Sunday, October 1, 2006, the Baltimore Museum of Art and the Walters Art Museum began having totally free admission year-round as a result of grants given by Baltimore City and Baltimore County.